Skok LabDepartment of Pathology, NYU Langone Health

People

Biologists, computational scientists and engineers working side by side on the 3D genome.

Members of the Skok Lab sitting together on a rooftop terrace with the Manhattan skyline behind them.
The lab, summer 2025
Portrait of Jane Skok

Jane Skok, PhD

Principal Investigator · Professor of Pathology

Jane Skok's interest in visualizing recombination in individual cells, tracing the dynamic changes in chromosome architecture and nuclear location at different stages of this complex process, unites two lifelong passions: science and art.

After completing her PhD in Immunology and Genetics at the Imperial Cancer Research Fund in Lincoln's Inn Fields, Jane took 12 years off and pursued training in art while caring for her young children. She then returned to science, joining David Gray's lab at Imperial College London as a postdoctoral fellow to study B cell biology and acquiring expertise in Mandy Fisher's lab to understand how the nuclear organization of the antigen receptor genes helps regulate V(D)J recombination.

Jane continued to pursue these questions in her own lab at University College London and elucidated the roles of Pax5 in locus contraction, and nuclear sub-compartmentalization in establishing maintaining allelic exclusion. In 2006 she was recruited to New York University School of Medicine, where her lab has revealed the activities of several signaling factors in guiding B cell development. Here, the Skok lab made the surprising discovery that the RAG proteins and the DNA damage response factor ATM help ensure allelic exclusion at the immunoglobulin gene loci (Hewitt et al., 2009). Furthermore they discovered that RAG2 C-terminus and ATM control RAG activity to limit the number of potential translocation substrates through modulation of 3D conformation (higher order loops) and repositioning of uncleaved loci to repressive pericentromeric heterochromatin. Ongoing work in the lab is focused on understanding how localized and long-range chromatin contacts impact gene regulation in health and disease settings.

Current members

Join the lab
  • Portrait of Giulia Cova

    Giulia Cova, PhD

    Postdoctoral Fellow

    Background
    • Postdoctoral Fellow, Mundlos Lab, Max Planck Institute for Molecular Genetics, Berlin
    • PhD in Genetics, Molecular and Cellular Biology, University of Pavia and Max Planck Institute for Molecular Genetics
    • MSc in Medical and Pharmaceutical Biotechnology, University of Pavia
    • BSc in Biotechnology, University of Pavia
  • Portrait of Guimei Jiang

    Guimei Jiang, PhD

    Postdoctoral Fellow

    Background
    • PhD, State Key Laboratory of Biotherapy, with joint training at Tsinghua University, Beijing
    • MSc in Preventive Immunology, Jilin University, Changchun
    • BSc, Jilin University, Changchun
  • Portrait of Annia Carre Simon

    Annia Carre Simon, PhD

    Postdoctoral Fellow

    Background
    • PhD in Genetics, Fabre Lab, Hôpital Saint-Louis, INSERM, University of Paris
    • MSc in Genetics, University of Paris
    • BSc in Biomedicine, University of Barcelona
  • Portrait of Gabriela Bianchi Leao

    Gabriela Bianchi Leao

    Pediatric Hematology/Oncology Fellow

    Background
    • Pediatric Hematology/Oncology Fellow, NYU (2025–present)
    • Pediatric Residency, University of Florida College of Medicine Jacksonville (2022–2025)
    • Medical School, University of the State of Rio de Janeiro, Brazil
  • Portrait of Elyes Ben Ahmed

    Elyes Ben Ahmed

    Predoctoral Fellow

    Background
    • Master’s student in Engineering, Mines Paris–PSL, Paris
    • Preparatory Classes (CPGE) in Mathematics, Physics and Chemistry, Lycée Sainte-Geneviève, Versailles
  • Portrait of Louis Maguer

    Louis Maguer

    Predoctoral Fellow

    Background
    • Master’s student in Engineering (Applied Mathematics, Computer Science, Physics), Mines Paris–PSL, Paris
    • Preparatory Class (CPGE) in Mathematics and Physics, Lycée Louis-le-Grand, Paris
  • Portrait of Lara Ladney

    Lara Ladney

    Lab Manager

    Background
    • MSc in Bioinformatics, Kanzok Lab, Loyola University Chicago
    • BSc in Molecular Biology and Cellular/Molecular Neuroscience, Loyola University Chicago

Alumni

Former members have gone on to lead labs at the NIH, the Institut Cochin and the Institut Curie, and to research roles in industry.

  • Ramya Raviram, PhDAssistant Professor; earlier a PhD student in the lab
  • Margarita Karapetian, PhDPostdoctoral Fellow
  • Oscar Pundel, PhDPostdoctoral Fellow
  • Tom SchippkePredoctoral Fellow
  • Camille HuaPredoctoral Fellow
  • Manel WafraPredoctoral Fellow
  • Catherine Do, PhDAssistant Professor
  • Tristan Montalbetti, PhDPredoctoral Fellow
  • Kiyomi ArakiLab Manager
  • Stephanie BelliniComputational Research Intern
  • Theodoros Sakellaropoulos, PhDPostdoctoral Fellow
  • Ariel Kuan, PhDPostdoctoral Fellow
  • Nata Kakabadze, MScAssistant Research Scientist
  • Aram Modrek, MD, PhDAram Lab at USC
  • Raphael Silveira Vidal, PhDAssociate Research Scientist
  • Anupama VermaResearch Technician
  • Nishana Mayilaadumveettil, PhDPostdoctoral Fellow
  • Priscillia Lhoumaud, PhDPostdoctoral Fellow
  • Fara Faye D. Regis, DVMAssociate Research Scientist
  • Roxanne Debaugny, PhDPostdoctoral Fellow
  • Javier Rodriguez HernaezData Analyst
  • Sana Bendaoud BadriPhD Student, Biomedical Informatics Program
  • Veronica Uribe-Echevarria, PhDPostdoctoral Fellow
  • Anil Vittal KanthiData Analyst
  • Ali RanjbaranResearch Data Associate
  • Caryn HaAssistant Research Technician
  • Ester Marina ZárateVisiting Student
  • Jason WongPhD Student, Molecular Oncology and Tumor Immunology Program
  • Erica ChioUndergraduate Student
  • Nikolaos Vosnakis, PhDPostdoctoral Fellow
  • Paul Vrana, PhDResearch Associate Scientist/Lab Manager
  • Lili BlumenbergPhD Student, Genome Integrity Program
  • Gunjan SethiaData Analyst
  • Deirdre GreenidgeMasters Student
  • Daniel BowerMasters Student
  • Yi LiLab Manager
  • Pedro Rocha, PhDPrincipal Investigator, NIH-NICHD
  • Jeanne KimLab Technician
  • Jeanne AllinneStaff Scientist at Regeneron Pharmaceuticals, Inc.
  • Valentina SnetkovaPh.D. Student, Stem Cell Biology Program
  • Arafat AljoufiTechnician, Columbia University, New York, USA
  • Beth CarellaBone Marrow Transplantation Fellow, Memorial Sloan Kettering Cancer Center
  • Mariann MicsinaiSenior Data Scientist at Pivotal Inc.
  • Julie ChaumeilPrincipal Investigator, Cochin Institute, Paris, France
  • Susannah HewittScientist, Onkaido Therapeutics, Boston
  • Kristen J JohnsonSenior Principal Scientist at Pfizer CTI
  • Charlotte ProudhonDirector of Clinical Biomarker Group, Curie Institute, Orsay University, Paris, France
  • Bingtao HaoPrincipal Investigator, Southern Medical University, Guangzhou City, Guangdong, China
  • Hongxi Chen
  • JungHyun Kim
  • Yi FuGraduate Student, NYU Sackler Institute, New York, USA
  • Vincent LuoGraduate Student, McGill University, Canada
  • Joy Wang